His Bundle Pacing: A New Strategy for Physiological Ventricular Activation

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Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation.

BACKGROUND Direct His-bundle pacing (DHBP) produces synchronous ventricular depolarization and improved cardiac function relative to apical pacing. Although it has been performed transiently in the electrophysiology laboratory and persistently in open-chested canines, permanent DHBP in humans has not been achieved. METHODS AND RESULTS A total of 18 patients aged 69+/-10 years who had a histor...

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Rapid reversal of right ventricular pacing–induced cardiomyopathy by His bundle pacing

Case report A 78-year-old woman with hypertension, paroxysmal atrial fibrillation treated with pulmonary vein isolation 4 years prior, and normal biventricular systolic function presented with symptomatic high-grade heart block with junctional escape rhythm and QRS duration of 84 ms (Figure 1A). She underwent dual-chamber pacemaker implantation with apical RV lead placement and resolution of he...

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His Bundle Pacing: Techniques and Outcomes.

Traditional right ventricular pacing prolongs the electrical and mechanical activation of the heart, which reduces the pump function, and in selected patients may lead to pacing-induced heart failure. Pacing the His bundle preserves the normal or near-normal activation pattern of the ventricles that prevents the detrimental effects of right ventricular pacing. This review discusses the techniqu...

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Simultaneous His Bundle and Left Ventricular Pacing for Optimal Cardiac Resynchronization Therapy Delivery

The beneficial effects of cardiac resynchronization therapy (CRT) have been evaluated in several trials, and different degrees of response to CRT have been reported; indeed, the optimization of pacing sites and stimulation timing seems to be a major determinant of the hemodynamic response. For standard CRT delivery, the atrioventricular pacing interval is shortened to ensure consistent left ven...

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Acute His Bundle Injury during Permanent His Bundle Pacing: Mechanistic Insights into Intra- Hisian Block

Permanent His bundle pacing (HBP) is a physiological alternative to right ventricular pacing. Acute injury to the His bundle can occur during permanent HBP in the form of transient or permanent bundle branch blocks. Observations of mechanical injury to the His bundle during HBP lead fixation and electrophysiological response to HBP provides additional mechanistic insights into the pathology of ...

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ژورنال

عنوان ژورنال: Journal of the American Heart Association

سال: 2019

ISSN: 2047-9980

DOI: 10.1161/jaha.118.010972